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  1. Precisely how topiramate prevents migraine is unclear, but, generally speaking, it appears to reduce the genetically derived brain hyperexcitability that provokes migraine attacks in susceptible individuals. As a potent, brain-active medication, topiramate is not without potential side effects
  2. About topiramate In people with migraine, it is thought that some chemicals in the brain increase in activity and, as a result, parts of the brain then send out confused signals which result in the symptoms of headache and sickness
  3. Topiramate is indicated for the prevention of migraine in adults. It is taken by mouth as preventive therapy to reduce migraine frequency. For those with frequent migraine attacks, or migraine that do not respond to acute treatment, preventive medications can be important. How does topiramate work

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The objectives of this paper are to evaluate the efficacy and tolerability of topiramate, given at the dose of 100 mg/day, in the prophylactic treatment of migraine. The hypothesis that migraine is the result of a condition of neuronal hyperexcitability and the quest for drugs that are able to limit Originally developed for epilepsy, Topamax (topiramate) is often one of the first drugs considered for Migraine prevention. Topamax (Topiramate) Quick Facts Topamax is a billion-dollar drug & one of the most commonly prescribed migraine preventative drugs in the USA. Topamax helps to prevent both M igraine and epilepsy to prevent seizures Topiramate is used to treat seizures in adults and children who are at least 2 years old. Topamax is also used to prevent migraine headaches in adults and teenagers who are at least 12 years old. This medicine will only prevent migraine headaches or reduce the number of attacks. It will not treat a headache that has already begun To help prevent migraine, up to 100 mg of Topamax be taken daily by people over the age of 12, administered in two doses. The recommended starting dosage is 25 mg of Topamax taken once each..

-Daily topiramate doses above 1600 mg have not been studied. -Co-administration with phenytoin and/or carbamazepine may require dose adjustments Using Topiramate in the Treatment of Migraine The number one drug used by neurologists for migraine and daily headache, topirimate, is still reluctantly used by primary care physicians. This article is an attempt to demystify a very effective medication in the physician's migraine armentarium. By R. Steven Singer, M Topiramate is an antiepileptic drug used as preventive therapy for migraines. 2 This meta-analysis studied whether topiramate was effective in reducing the occurrence of migraines and/or improving.. Trokendi XR® (topiramate) extended-release capsules are used to prevent migraine headaches in adults and adolescents 12 years and older. Please refer to the Medication Guide for additional important patient information. You are encouraged to report negative side effects of prescription drugs to the FDA

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Topamax (topiramate) is an anticonvulsant medication used in the treatment of epilepsy and migraine headaches. 1  Topamax is also commonly used off-label to treat a wide range of mood disorders, eating disorders, and to aid in substance abuse therapy The recommended dosage of topiramate for migraine prevention is 100 mg/day (50 mg twice daily), which is less than the target anti-epileptic dose. Some patients benefit from a lower dose (for example, 50 mg/day). In clinical trials, around 50% of patients using topiramate experienced paraesthesia Topiramate (Topamax) is an antiepileptic drug recently approved by the U.S. Food and Drug Administration (FDA) for prevention of migraine headache in adults. Its exact mechanism of action is.. Topiramate will not treat a migraine headache once it occurs. If you get a migraine headache, treat it as directed by your doctor (such as by taking pain medication, lying down in a dark room) Topamax can be tough to withdraw from. Most people decrease by 25 mg a week. However, it may be done slower, perhaps 25mg every two weeks. Of course this needs to be discussed with your doctor before doing so. I've heard from many people who tapered off Topamax only to have their migraine attacks come back

Topiramate reduces headache days in chronic migraine: a

  1. Topamax (topiramate) is a drug approved to treat seizures in adults and children and to reduce the frequency of migraine headaches in people 12 years of age and older. For the treatment of seizures, Topamax may be used alone or in combination with other medications. Johnson & Johnson subsidiary Janssen Pharmaceuticals manufacturers Topamax
  2. Topiramate is a medicine used to treat epilepsy. These are also called anti-epileptic medicines. It can also be taken to prevent migraine. This medicine is only available on prescription
  3. Topamax associated side effects are reported to occur in approximately 70% of individuals prescribed the medication for prevention (prophylaxis) of migraines. The most commonly reported side effects are a burning or prickling sensation in the hands, legs or feet ( paresthesia ), fatigue, nausea, difficulties with concentration, taste.
  4. istration (FDA) approval for that purpose, it subsequently was shown to be effective for the prevention of migraine headaches and is FDA approved for that indication as well
  5. Topiramate is also used with other medications to control seizures in people who have Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). Topiramate is also used to prevent migraine headaches but not to relieve the pain of migraine headaches when they occur

Compared with placebo, topiramate reduced the frequency of migraine headaches by approximately 1.2 per month (nine studies, 1737 participants). Patients were also about twice as likely to reduce the number of their migraine headaches by 50% or more with topiramate than with placebo (nine studies, 1190 participants) Scientific studies suggest topiramate reduces brain hyperexcitability, which is thought to provoke migraine attacks in those susceptible. The ways in which a drug works is often referred to in clinical papers as its mechanism of action. Topiramate's mechanism of action may involve [iii] What is Topamax (topiramate)? Topamax (topiramate) is an anticonvulsant (antiepileptic drug) used alone or with other medications to prevent and control seizures (epilepsy). Topamax is also used to prevent migraine headaches and decrease how often they occur. Topamax will not treat a migraine headache once it occurs The recommended total daily dose of TOPAMAX® as treatment for patients 12 years of age and older for prophylaxis of migraine headache is 100 mg/day administered in two divided doses (Table 3). The recommended titration rate for TOPAMAX for migraine prophylaxis is as follows

BOTOX® Can Help. See Full Safety & Prescribing Info, Including Boxed Warning. Use Our Doctor Discussion Guide to Get the Conversation Going on a Treatment Option Today Increasing evidence shows that migraine, typically considered as an episodic disease, is a chronic and, in some patients, progressive disorder. Among neuromodulators used for migraine prevention, topiramate has a high level of evidence-based efficacy.. Topiramate (generic Topamax®) is a preventive prescription medication that's proven to help reduce the frequency and severity of migraine headaches. What will it do for me? Topiramate, which is also an anticonvulsant medication , can, at lower dosages, act as a first line of defense when it comes to your migraines

Topiramate in the prevention and treatment of migraine

TOPAMAX ® is the #1 prescribed medication for migraine prevention in the U.S. and it is proven to significantly reduce migraine frequency. The studies of TOPAMAX ® are large, well-controlled clinical trials conducted for migraine prevention, involving over 1,700 adult patients Topiramate treatment resulted in a statistically significant mean reduction of migraine/migrainous headache days (topiramate −6.4 vs placebo −4.7, P= .010) and migraine headache days relative to baseline (topiramate −5.6 vs placebo −4.1, P= .032). Treatment-emergent adverse events occurred in 132 (82.5%) and 113 (70.2%) of topiramate. Topiramate (Topamax) is a medicine used to treat epilepsy and prevent migraines. It decreases overly active brain signaling and is used alone or combined with other antiepileptic medicines to treat seizures. Topiramate is also used to prevent migraine headaches

Topamax (topiramate) is one of the most widely prescribed drugs for migraines, but it carries many precautions. Before considering Topamax for migraine headache prevention, learn more about the possible debilitating side effects by talking to other topiramate users and reading the manufacturer's warnings. What is Topamax? Topamax is an anti-epileptic drug that is [ Topiramate Topiramate is effective at reducing monthly migraine frequency and monthly migraine days in trials. It is associated with a number of side effects including nausea, paraesthesia, anorexia and weight loss. In particular cognitive side effects ar Topamax Approved for Preventing Migraine . Migraine headaches are caused by overactive nerves in the brain which release chemicals that cause pain and inflammation of blood vessels in the brain Increasing evidence shows that migraine, typically considered as an episodic disease, is a chronic and, in some patients, progressive disorder. Among neuromodulators used for migraine prevention, topiramate has a high level of evidence-based efficacy. Through its wide range of mechanisms of action topiramate increases the activation threshold resulting in neuronal stabilization and thereby. prevent migraine headaches. How it works. Topiramate belongs to a class of drugs called sulfamate-substituted monosaccharide anticonvulsants or antiepileptic drugs (AEDs). A class of drugs is a.

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Topamax (Topiramate) is an anti-seizure medicine that is prescribed to adults and children above the age of two. It is also commonly prescribed to help prevent the onset of migraine headaches. Patients must also understand that Topamax is effective in reducing the frequency of migraines only and does not cause migraines that have already begun. TOPAMAX ® is indicated for: Migraine. Adults and adolescents 12 years of age and older for the prophylaxis of migraine headache. The usefulness of TOPAMAX ® in the acute treatment of migraine headache has not been studied. Monotherapy Epileps Topiramate (TPM) has shown efficacy in migraine prophylaxis in two large placebo-controlled, dose-ranging trials. We conducted a randomised, doubleblind, multicentre trial to evaluate the efficacy and safety of two doses of topiramate vs placebo for migraine prophylaxis, with propranolol (PROP) as an active control. Subjects with episodic migraine with and without aura were randomised to.

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Topiramate has multiple mechanisms of action that could contribute to migraine prevention, including state-dependent inhibition of voltage-gated sodium channels, inhibition of high-voltage-activated calcium channels, inhibition of glutamate-mediated neurotransmission at α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid and kainate. Topamax (topiramate) is an anticonvulsant prescribed for preventing epileptic seizures and migraine headaches. Topamax is available as a generic drug. What Are Side Effects of Topamax? Common side effects of Topamax include: tiredness, drowsiness, dizziness, nervousness, numbness or tingly feeling in the hands or feet, coordination problems. For tapering off topiramate, experts recommend revesing that and decreasing by 25 mg per week. You can read more about this in Dosage and Tapering Topamax for Migraine Prevention. I hope this. Topamax or topiramate is a seizure medication, which is also used to prevent migraine headaches in adults. However, it will only prevent migraine headaches or reduce the number of attacks and will not treat a headache that has already begun

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I've been taking Topamax for migraine prevention. Started at 25 mg per day and tapered up by adding 25 mg per week until I got to 100 mg twice a day. I started having symptoms of kidney stones. This video is about my experience using Topiramate (Topamax) as a potential treatment for Cervicogenic Headaches and Migraines. I talk about doses, side effe.. Topiramate has activity at multiple molecular targets, which may account for why it is effective in migraine and most other, more specific, anticonvulsants are not. Based on randomized controlled trials, topiramate reduces migraine frequency and acute medication use, improves quality of life, and reduces disability in patients with episodic. Hello all. Had the Migraine/ClusterHeadache to end them all on Monday and was in hospital for 3 days. they started me on Topiramate which I had been prescribed and had been due to pick the prescription up the day I went in The Childhood and Adolescent Migraine Prevention (CHAMP) trial tested the effects of amitriptyline and topiramate in comparison with each other and with placebo in pediatric migraine

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The secondary endpoint was efficacy of 70 mg and 140 mg erenumab versus topiramate in terms of at least 50% reduction in monthly migraine days to baseline in the last three months (months 4, 5 and 6) of the double-blind, 24-week treatment phase 5 in the highest tolerated dose (50-100 mg daily) Can Topiramate help people who have not found relief with other psychopharmacologics? That is precisely the role of Topiramate. It is effective for those who found no useful effect from other mood stabilizers. Potential new uses of the drug include PTSD and reducing alcohol cravings, as well as heading off migraine headaches

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Guidelines do not make recommendations regarding migraine prophylaxis with topiramate due to insufficient evidence. Oral dosage (extended-release capsules) Adults. 25 mg PO once daily for 1 week, then 50 mg PO once daily for 1 week, then 75 mg PO once daily for 1 week, and then 100 mg PO once daily. Adjust dose and titration according to. MIGRAINE TOPAMAX is indicated in adults for the prophylaxis of migraine headache. The usefulness of TOPAMAX in the acute treatment of migraine headache has not been studied. 4.2 DOSE AND METHOD OF ADMINISTRATION Dose For optimum seizure control in both adults and children, it is recommended that therapy should b

Topiramate in migraine prophylaxis: a randomised double

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Topamax for Migraines: Side Effects, Safety, and Mor

We've talked about nortriptyline, an antidepressant commonly prescribed for chronic pain, and topiramate, an anticonvulsant often used for migraine in particular, in the past.As you can see from the comments people leave here, both have been a wonderful help - or haven't been so great - depending on the patient AUTHORS' CONCLUSIONS: Meta-analysis demonstrates that topiramate in a 100 mg/day dosage is effective in reducing headache frequency and reasonably well-tolerated in adult patients with episodic migraine. This provides good evidence to support its use in routine clinical management. More studies designed specifically to compare the efficacy or. The Food and Drug Administration has approved a supplemental new drug application for the once-daily formula of topiramate (Qudexy XR, Upsher-Smith Laboratories Inc) to prevent migraine in adults and adolescents age 12 years and older, the company announced in a press release. 1 The extended-release drug may help improve patient adherence {{configCtrl2.info.metaDescription}} regarding the efficacy of topiramate for migraine prevention in children and adolescents. Based upon evidence from four trials , the 2019 AAN/AHS guideline concluded that topiramate was probably more effective Topiramate. Topiramate is a type of medicine originally developed to prevent seizures in people with epilepsy, but is now much more commonly used in migraine. It's been shown to help prevent migraines, and is usually taken every day in tablet form. Topiramate should be used with caution in people with kidney or liver problems

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Topamax for Migraine Prevention: Dosage and Mor

Topiramate, sold under the brand name Topamax among others, is a carbonic anhydrase inhibitor medication used to treat epilepsy and prevent migraines. It has also been used in alcohol dependence. For epilepsy this includes treatment for generalized or focal seizures. It is taken by mouth. Common side effects include tingling, loss of appetite, feeling tired, abdominal pain, hair loss, and. Topamax (TOH-pah-maks) is the brand name used in the United States, Canada, the United Kingdom, Australia, and some other countries for the seizure medicine topiramate (toh-PEER-ah-mate). Topamax is not available in generic (non-brand) form in the United States BOTOX® Can Help. See Full Safety & Prescribing Info, Including Boxed Warning. Know What Your Symptoms Mean and Talk to Your Doctor to Find a Treatment Option For You

Topamax (topiramate) is an anticonvulsant, meaning it's used to prevent seizures for people who have epilepsy and related disorders. It's also prescribed to prevent certain types of migraine headaches for adults and adolescents age 12 and older. A migraine is more severe than a headache and often lasts longer (up to 72 hours) Topiramate, a newer generation AED, has broad mechanism of action and evidence of benefit in patients with either episodic or chronic migraine along with epilepsy, both generalized and focal. Methods Our goal is to review the relevant mechanisms of action along with any supportive evidence published to date on the use of topiramate (TPM) in. What is Topamax? Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 50,995 Topamax users for its effectiveness, alternative drugs and more. What is Migraine with aura? Migraine with aura (headache with vision weakness) is found to be associated with 858 drugs and 625 conditions by eHealthMe

Various visual and sensory phenomena have been described in migraine with aura. Among those, the Alice in Wonderland syndrome is defined as a distortion of the body image with the patient being aware of its unreal nature. Here, the case of a 17-year-old girl with migraine without aura who developed an 'Alice in Wonderland' syndrome repeatedly on topiramate treatment was presented and. Hi Topamax (topiramate) is indicated in adults for the prophylaxis of migraine attacks. Its usefulness in treating acute episodes of migraine headache has not been established. The most common side effects seen during clinical trials of topamax in preventing frequently recurring migraines were tiredness, pins and needles in the fingers and toes, dizziness, nausea, diarrhea, indigestion, dry. I've been taking Topamax for migraine prevention. Started at 25 mg per day and tapered up by adding 25 mg per week until I got to 100 mg twice a day

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Topiramate (Topamax) Hello fellow Migraine Sufferers! I was recently prescribed Topamax 25 mg tablets as Migraine preventatives. I'm calling on the help from Migraine suffers that have or are currently taking Topamax for Migraine prevention. I am wondering if you've felt any side effects (and if so, which ones) because I'm in my teens Her medical history was very important in this case—she was a chronic migraine sufferer, and her internist had just started her on a migraine medication called Topamax (topiramate, Ortho-McNeil Neurologics). In this case, the patient had suffered from a medically-induced sudden myopic shift and angle closure due to Topamax Topamax (an anticonvulsant under the generic name Topiramate and in time release Trokendi XR) is important to discuss because it was initially formulated as a diet pill. Yet over 50% of the new members who join my migraine group arrive with Topamax on their prescription list. I have yet to find a single person on this drug who is not seriously. Once-daily Qudexy ® XR is a prescriptionmedicine that can be used: To prevent migraine headaches in adults and adolescents 12 years and older. To treat certain types of seizures (partial-onset seizures and primary generalized tonic-clonic seizures) in adults and children 2 years and older. With other medicines to treat certain types of.

Then comes Zolmitriptan 2.5mg oral, Ibuprofen 200 or 400mg oral, Sumatriptan Nasal Spray, Aspirin 1000mg oral, Diclofenac 50mg oral, Paracetamol 100mg oral, and last is Naproxen 500mg or 825mg oral. Naproxen is not a good drug to treat migraines, it was only slightly more effective than the placebo. The takeaway: Sumatriptan via injection is. Generic Name Topiramate DrugBank Accession Number DB00273 Background. Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. 4 It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. 6,19 Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight. Topamax is a medication that is commonly prescribed to patients suffering from migraines and seizures. This medication is believed to alleviate symptoms by blocking chemicals in the brain that cause inflammation in the blood vessels

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The top choice: Topamax (Topiramate), an anticonvulsant, epileptic medication used with relative success for some migraines. One of the first things my Neurologist said to me about Topamax was: Now, Victoria, one of the most serious side effects of Topamax is weight loss Topamax, also known by its generic name topiramate, belongs to a category of drugs known as anticonvulsants. Doctors prescribe it to treat epilepsy and to prevent migraine headaches, as well as for off-label, or unapproved, uses. Janssen Pharmaceuticals (formerly Ortho-McNeil) is a Johnson & Johnson subsidiary

Topamax (Topiramate) is specifically indicated for children 12 years and older for migraine prophylaxis. It is a very commonly prescribed drug because it is the ONLY FDA approved medications for adolescents. There is unfortunately a downside to topiramate as it can cause a good number of side effects in people I originally started taking Topamax for migraines and at just 25mg two times a day. I went through a family tragedy and could not study/work so I asked the doctor for ADD tablets (through a referral) at the time, I was not taking Topamax I was taking Maxalt as I was doing IVF. As you know Topamax and pregnancy is a no-no Topiramate is a medicine used to treat certain types of seizures. This drug is also sometimes given to help prevent migraine headaches from occurring

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The recommended total daily dose of topiramate for prophylaxis of migraine headache is 100 mg/day administered in two divided doses. Titration should begin at 25 mg nightly for 1 week. The dosage should then be increased in increments of 25 mg/day administered at 1-week intervals The purpose of this study is to determine the safety and efficacy of 70 mg and 140 mg AMG 334 compared to topiramate in the highest tolerated dose in patients suffering from at least 4 migraine days/months, who are naïve or not suitable for or have previously failed up to three prophylactic migraine treatments The first successful randomized controlled trial of migraine prevention in adolescents the United States has shown topiramate reduces migraine frequency and severity in children aged 12 to 17 years Topamax, however, cannot help a migraine that has already started. If your child were to stop taking her Topamax suddenly, she might have seizures, even if she never had them before. Many people who take Topamax are uncomfortable because of the side effects of the drug, which can include mood and behavior changes 1.3 Migraine . TOPAMAX ® Tablets and TOPAMAX ® Sprinkle Capsules are indicated for adults for the prophylaxis of migraine headache [see Clinical Studies (14.3)]. The usefulness of TOPAMAX ® in the acute treatment of migraine headache has not been studied. 2 DOSAGE AND ADMINISTRATION . 2.1 Epileps

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Patients who experienced 3 to 12 migraine attacks (according to migraines classified by patient reported diaries) and ≤14 headache days (migraine and non-migraine) during the 4-week prospective baseline period were randomized to either topiramate 50 mg/day, 100 mg/day, or placebo and treated for a total of 16 weeks (4-week titration period. Erenumab Bests Topiramate in Head-to-Head Migraine Prevention Study. Brian Park, PharmD. Findings showed a higher proportion of patients remained on treatment with erenumab compared with. The epilepsy and migraine drug Topamax, which is also available as generic topiramate, has been associated with an increased risk of major birth defects. Research has found higher than expected rate

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• Trokendi XR (topiramate) extended-release capsules are indicated for prophylaxis of migraine headaches in patients 12 years of age and older. Please refer to the full Prescribing Information and Medication Guide for additional important information on Trokendi XR. Trokendi XR (topiramate) extended-release capsules for oral us Topiramate is used to treat patients who continue to have seizures even when they take other anti-seizure medications. Topiramate is also used to prevent migraine headaches, but not to relieve the pain of migraine headaches when they occur. Topiramate is in a class of medications called anticonvulsants This study investigated another type of carbonic anhydrase inhibitor and antiepileptic drug, zonisamide, in order to evaluate its potential effectiveness for migraine prophylaxis refractory to topiramate, and to assess intolerability to adverse events, paresthesia in particular. This is an open-labeled retrospective single center study. We included headache patients who met the requirement of. Valproate and topiramate (Topamax, Qudexy XR, others) might help if you have less frequent migraines, but can cause side effects such as dizziness, weight changes, nausea and more. These medications are not recommended for pregnant women or women trying to get pregnant. Botox injections

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Pediatric migraine is a disabling condition, which can cause a significant impact on quality of life. Currently, no drugs have been approved by the FDA for its preventive treatment. Our aim was to review the medical literature concerning the efficacy and tolerability of topiramate in the prophylactic treatment of migraine in children and adolescents 2013: Efficacy and safety of topiramate in migraine prophylaxis: an open controlled randomized study comparing Sincronil and Topamax formulations. A study conducted by Cosentino et al. (2013) aimed to analyze the efficacy, tolerability, and safety of topiramate for the prophylaxis of migraine without aura Hello, hoping some fellow migraineures can give me a bit of advice Having had 3 migraines in the last week and one that started Friday afternoon, kept me up all night and in bed until 3pm yesterday, I have started taking topiramate 25mg, which the dr prescribed a while ago but I had been too scared to take

Novartis' injectable migraine prevention antibody Aimovig has been shown to be more effective than topiramate - a go-to oral therapy for people with chronic migraine - in a head-to-head trial Topiramate is an antiepileptic medication used to prevent seizures and migraine headaches. It has also been used to treat alcoholism, eating disorders, tremors, obesity, diabetes and psychiatric disorders such as bipolar disorder. Topiramate is sold under the brand names Topamax®, Trokendi XR®, Qudexy XR®) Young children: Frequent migraine. These preventive medications may be prescribed: Cyproheptadine (Periactin®), amitriptyline (Elavil®), topiramate (Topamax®), or gabapentin (Neurontin®) A combination of symptomatic (from list above) and preventive medications; Adolescents: Infrequent migraine (with or without aura

Currently topiramate is approved as an anti-convulsant for treatment of seizure disorders and for prevention in adults of migraine headaches